The Age-Sensitive Efficacy of Calorie Restriction on Mitochondrial Biogenesis and mtDNA Damage in Rat Liver

Calorie restriction (CR) is the most efficacious treatment to delay the onset of age-related changes such as mitochondrial dysfunction. However, the sensitivity of mitochondrial markers to CR and the age-related boundaries of CR efficacy are not fully elucidated. We used liver samples from ad libitum-fed (AL) rats divided in: 18-month-old (AL-18), 28-month-old (AL-28), and 32-month-old (AL-32) groups, and from CR-treated (CR) 28-month-old (CR-28) and 32-month-old (CR-32) counterparts to assay the effect of CR on several mitochondrial markers. The age-related decreases in citrate synthase activity, in TFAM, MFN2, and DRP1 protein amounts and in the mtDNA content in the AL-28 group were prevented in CR-28 counterparts. Accordingly, CR reduced oxidative mtDNA damage assessed through the incidence of oxidized purines at specific mtDNA regions in CR-28 animals. These findings support the anti-aging effect of CR up to 28 months. Conversely, the protein amounts of LonP1, Cyt c, OGG1, and APE1 and the 4.8 Kb mtDNA deletion content were not affected in CR-28 rats. The absence of significant differences between the AL-32 values and the CR-32 counterparts suggests an age-related boundary of CR efficacy at this age. However, this only partially curtails the CR benefits in counteracting the generalized aging decline and the related mitochondrial involvement.     

基于C#持久蠕变强度外推功能的实现

持久蠕变强度外推是预测材料在高温高压环境下工作寿命的有效方法。目前常用的外推方法有等温法和参数法。这两种方法都是通过在实验室中采用较短时间的试验，获取试验数据后，通过Excel或者MATLAB等数据处理软件进行数据的拟合处理和外推计算。这些数据归纳统计和数学建模的过程有时需要耗费试验人员的大量精力。介绍了持久蠕变强度外推的软件实现方法，该功能包含在持久蠕变试验设备配备的软件中，试验完成后，软件直接根据试验结果进行数据拟合和持久蠕变强度的外推计算，无需试验数据的统计和建模，大大提高了持久蠕变强度外推计算的效率。     

High energy-storage performance of lead-free AgNbO3 antiferroelectric ceramics fabricated via a facile approach

AgNbO₃ lead free AFE ceramics are considered as one of the promising alternatives to energy storage applications. In the majority of studies concerning the preparation of AgNbO₃ AFE ceramics, an oxygen atmosphere is required to achieve high performance, increasing the complexity of the fabrication process. Herein, a facile approach to preparing AgNbO₃ ceramics in the ambient air was reported, in which the AgNbO₃ ultrafine powder with stable perovskite structure was synthesized by hydrothermal method instead of the conventional ball milling process, leading to a lower temperature of phase formation and thus smaller grain size. The resulting ceramics sintered at 940 °C displayed high breakdown strength (216 kV/cm) and a recoverable energy density of 3.26 J/cm³ with efficiency of 53.5 %. Also, the high thermal stability of recoverable energy density (with minimal variation of ≤20 %) and efficiency (≤ 10 %) over 30–150℃, enables AgNbO₃ ceramics achieved to be a promising candidate for energy storage applications.     

Effects of environmental factors on corrosion behavior of aluminum

Aluminum, used as a material for heat exchangers in air conditioners, often has problems of leakage of refrigerant on the Al surface due to corrosion. The problems originate from pitting corrosion of the Al in an external environment. To understand corrosion problems, it is necessary to study the corrosion behavior of Al in various environments. In this study, the effects of environmental factors on the corrosion behavior of Al were studied by the surface analysis and electrochemical testing in 3.5 wt% NaCl solutions, with changes of dissolved oxygen, temperature, and concentration of Cl⁻ and S ions. Among the external environmental factors, the presence of oxygen and the increase of Cl⁻ ion concentration do not significantly affect the corrosion potential of Al, leading to an increase of only 1.1 and 6 times, respectively. There was a significant decrease in the corrosion resistance of Al, approximately 40 and 800 times, respectively, with the increase of concentration of S and temperature.     

基于云网PoP的弹性边缘网络设计思路探讨

移动边缘云是公司“云+5G”双引擎战略的最佳契合点,边缘网络是发挥移动云“大云”产品和5G网络融合优势,实现云网统筹、构建运营商“连接+计算”核心能力的关键。运营商传统接入网存在云网割裂、分段入云和组网复杂等突出问题,难以适应边缘业务敏捷交付要求。本文通过深入分析边缘云业务特征和技术架构,对标业界主流云商建设实践,研究基于云网PoP网的边缘网络建设思路,创新性提出云网一体化规划设计和建设交付流程变革,基于云网POP统一网络和业务锚点,构建Overlay和Underlay融合双层加速网络架构,探索Spine-leaf化的新型城域接入网实现L3下沉和弹性扩容等方法,实现“云+网+应用”一体化敏捷交付的边缘网络能力。     

一种基于实时几何测距的船桥主动防撞方法

本文提出一种基于实时几何测距的船桥主动防撞方法。该方法对船的改动量甚微,仅需维持多项距离矩阵,通过告警逻辑矩阵进行展示与告警,能起到很好的船桥防撞提示效果。     

Controlled synthesis of Ag2O/g-C3N4 heterostructures using soft and hard templates for efficient and enhanced visible-light degradation of ciprofloxacin

Pluronic 31R1 surfactant and MCM-41 silica were used to fabricate mesoporous Ag₂O/g-C₃N₄ heterostructures with improved surface areas. The fabricated mesoporous nanocomposite was used to photo oxidize ciprofloxacin. The TEM images of Ag₂O/g-C₃N₄ indicated a uniform dispersion of spherical approximately 4-nm Ag₂O nanoparticles on g-C₃N₄. The mesoporous 0.9% Ag₂O@g-C₃N₄ heterostructure exhibited 100% efficiency in ciprofloxacin oxidation within 60 min when compared with the 25% efficiency in 120 min of pure mesoporous Ag₂O and 10% efficiency in 120 min of pure g-C₃N₄. The highest ciprofloxacin oxidation efficiency achieved was 100%, which was four and ten times better than those of Ag₂O and g-C₃N₄, respectively. This superior performance of the mesoporous Ag₂O/g-C₃N₄ was attributed to the high dispersion of nano-sized mesoporous Ag₂O particles on the g-C₃N₄ surface, narrow bandgap, and significantly high surface areas. The powerful interaction between Ag₂O and g-C₃N₄ ensured robust durability of Ag₂O/g-C₃N₄ heterostructures, which is evident in the fact that five recycling trials of the photocatalyst rendered a minimal loss of efficiency.     

Microstructure induced ultra-high energy storage density coupled with rapid discharge properties in lead-free Ba0.9Ca0.1Ti0.9Zr0.1O3–SrNb2O6 ceramics

Novel lead-free (1-x)Ba_0·9Ca_0·1Ti_0·9Zr_0·1O₃-xSrNb₂O₆ ceramics were synthesized via a two-step high energy ball milling process. The evolution of microstructural properties, phase transformation, and energy storage characteristics was comprehensively investigated to assess the applicability of material in multi-layered ceramic capacitors. The substitution of SrNb₂O₆ (SNO) in Ba_0·9Ca_0·1Ti_0·9Zr_0·1O₃ (BTCZ) has resulted in substantial improvement in materials density along with a small increase in the grain size of the synthesized ceramic. A thorough microstructural investigation indicates an excellent dispersibility and compatibility between BTCZ and SNO phases. With an increase in SNO substitution, a transition from typical ferroelectric to relaxor ferroelectric has been observed, which has led to a significantly slimmer ferroelectric loop along with frequency dispersive dielectric properties. The optimized composition (i.e., x = 0.10) exhibits an ultra-high recoverable energy density of 2.68 J/cm³ along with a moderately high energy efficiency of 83.4%. Further, SNO substituted samples have also shown an enhancement in breakdown strength. The improvement in energy storage performance and breakdown strength of SNO substituted BTCZ composites are mainly attributed to relatively homogeneous grain morphology, optimum grain size, microstructural density, and improved grain boundary interface.